Some of the doctors listed on our Medical Professionals page may also recommend such strategies. Hi man, Id use pregnenolone and D-phenylalanine to counter the long term sides. 2020 Jan;113(1):21-50. doi: 10.1016/j.fertnstert.2019.11.030. Some men with PFS report symptoms that last for years after stopping finasteride. WebPost-finasteride syndrome (PFS) describes persistent sexual, neurological, physical, and mental adverse reactions in patients who have taken finasteride, a 5-alpha reductase type What few people know is that there are 5-R and 3 types of 5-R enzymes and that theyre not only involved in the conversion of testosterone to DHT, but also in the: Many of the benefits of testosterone, such as enhanced insulin sensitivity, reduced catabolism, higher dopamine, increased thyroid hormone production, are mediated by DHT, and blocking DHT production prevents those effects/benefits. Unlike finasteride, you dont need a doctors prescription to purchase and use this medication. When used together, men saw better results in clinical trials compared to using either alone. The https:// ensures that you are connecting to the You can argue with the theoretician but you cant argue with the anecdotal stories of successful recovery. Disclaimer. For example, the rate of erectile dysfunction increases from just over eight percent for men in their 40s to more than 77 percent for men aged 75 or older. Federal government websites often end in .gov or .mil. It can be reversed yes. Q20: Im a PFS patient and Id like to do my part for PFS research by participating in a clinical study on the condition. Q9: After describing my PFS symptoms to my doctor, he/she said he/shed never heard of the condition. Since testosterone is an important hormone for sexual desire and function, this could cause a reduction in libido. Would you like email updates of new search results? I can definitely have a look for you and see if I find anything that needs optimization. I know, that there are people who recoveredTo you PLEAAASE post some encouraging stuff for the rest of us.. Im 5 weeks off propecia, und total numbness in my penis, low libido, suicide ideation und shooting pain in my shaft.. If youd like to suggest adding one, please email patient manager Philip Roberts at proberts@pfsfoundation.org.). The depression of PFS can be very debilitating and finding effective treatments for the depression of PFS can be challenging and require considerable trial and error in consultation with your doctor. A: Most likely, yes. Our Support staff will manually approve your account within 24 hours, and you will get a notification. Any idea why that may be? Learn how your comment data is processed. Rather, these Frequently Asked Questions are meant as a starting point for ongoing discussions among patients, doctors and researchers. I think progesterone is high because its not converted further downstream possibly due to 5AR downregulation. official website and that any information you provide is encrypted Low levels of these hormones increase glutamate and may account for the appearance of behavioural disorders such as anxiety, aggression, and cognitive dysfunction. Learn more about our editorial standards here. no libido Press question mark to learn the rest of the keyboard shortcuts. Q17: Can finasteride have an impact on male fertility? Clipboard, Search History, and several other advanced features are temporarily unavailable. The program can also connect the loved ones of PFS patients who have taken their own lives with the loved ones of other PFS patients who suffered the same fate. Disproportionality analysis based on both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases. It would be something if I could get referred to an endocrinologist and expect some understanding, but my impression is thats not how it goes. The truth of vitamin B6 on DHT for hair growth. Lets say your DHT is low, here are the top 7 supplements you can use to increase it: If you want additional methods on increasing DHT apart from supplements, check out my comprehensive article on boosting DHT: If DHT is normal and you still feel off, mainly anxious, not confidence, shy, nervous, experiencing brain fog, etc., you might be low in allopregnanolone. Practo Consult. Feel free to discuss remedies, research, technologies, hair transplants, living with hair loss, cosmetic concealments, whether to "take the plunge" and shave your head, and how your treatment progress or shaved head or hairstyle looks. Q4: Is there any way to know if Im susceptible to PFS? I want to try HCG 50 UI per day. You definitely want high dopamine and low serotonin to optimize cognition and mindset. WebPost-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) How much Glycin and Niacinamid do you recommend? We require a human profile pic upon registration on this forum. WebThis endocrine crash usually occurrs a few days or weeks after the cessation of treatment with 1 mg finasteride in these patients. Hi, no I dont have insomnia. Anyone wishing to connect with other PFS patients and/or their family members should download our Patient Support form, complete it and email it back to us at social@pfsfoundation.org. Clinically proven to regrow hair in 3-6 months, no pills required. With that in mind, DHT can take anywhere from4 weeks to 2 years or more to recover(R). If you stop with fin, then DHT should be back to normal in about 1-2 weeks (tissue binding lasts 4-5 days). The .gov means its official. National Library of Medicine Support inquiries will not be addressed. RX MEDS SHIP FREE, IF PRESCRIBED. Here we evaluate the scientific and clinical evidence in the contemporary medical literature to address the very fundamental question: Is PFS a real clinical condition caused by finasteride use or are the reported symptoms only incidentally associated with but not caused by finasteride use? At this point, you will not yet be registered on the forum. As more studies are conducted, we may learn more about the possible link between finasteride and the reports of various long-term symptoms. government site. Bethesda, MD 20894, Web Policies Thanks man, much appreciated. Kaplan-Marans E, Sandozi A, Martinez M, Lee J, Schulman A, Khurgin J. I look and feel so much younger!, When I show my barber my progress, he is always in disbelief. Androsterone worked wonders for me. After finasteride is discontinued, the body must produce new 5-alpha-reductase molecules to replace the ones that were inactivated by the finasteride. I wish you could share more research about how you chose to do it. Also I dont know how the Sun in Australia would affect you differently maybe the ozone layer there would filter less UV and you gotta take that into account Im sure that has been said somewhere by JK. Brain fog 2019 Jan 1;99(1):12-17. doi: 10.2340/00015555-3035. Some say its all in the mind, a made-up mythbut those who suffer from it surely know theyre not just a hypochondriac. 2022 Hims & Hers Health, Inc. All rights reserved. The first of these is the nocebo effect. Huperzine-A, Uridine, Bacopa Monnieri, Phosphatidylserine, Alpha-GPC, Caffeine. Common adverse events of treatment consist of sexual disorders and a negative affect balance. I also had dysbiosis in my gut which is slowly being resolved with the help of probitics. Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis. In 2013, Swiss pharmaceutical company Polichem SA conducted a study, published in the Journal of the American Academy of Dermatology and titled Single and repeated dose of finasteride topical solution in subjects with androgenetic alopecia, which showed that topical finasteride is absorbed and lowers serum DHT levels almost to the same degree as the oral medication. You have had fires in this area? Here are a few things you can do: Finasteride binds to 5-R type 2 with high affinity and dissociates very slowly with a half-life of 31 days. HIMS, HERS, H, and HIMS & HERS are trademarks of Hims, Inc. Get medication to your doorstep, if prescribed. PMC Do explosive exercises, such as uphill sprints, muscle-ups, jump squats, burpees, etc. In a small study published in the Journal of Sexual Medicine in 2007, men with benign prostatic hyperplasia were divided into two groups and treated with finasteride. You do think that these hypothetical damages can be reversed ? Berrima in the Southern Highlands in NSW, its a beautiful area. Would you like email updates of new search results? Dirt cheap too. It is important to note that many clinical studies suffer from incomplete or inadequate assessment of adverse events and often limited or inaccurate data reporting regarding harm. And then you would possibly absorb better the UV. Finally, weve explained your options for treating and preventing hair loss if youre worried about developing post-finasteride syndrome. This is a psychological phenomenon in which a persons negative expectations about a specific medication or procedure may cause them to experience a negative symptom. One such woman, Sara, was profiled in a 2016 documentary on the Belgian public TV, titled The Wonderhair Pill. This issue can have a serious impact on a persons risk of experiencing side effects after taking medication, as healthcare providers are required to inform their patients about the potential side effects of medication as part of the treatment process. MASA Traditional Tortilla Chips by Ancient Crunch, Vitamins, Minerals & Amino Acid Supplements, Enhanced stimulation of 5 alpha-reductase activity in cultured Leydig cell precursors by human chorionic gonadotropin. The treatment worked miraculously well and within a few months I was In some people with PFS, DHT might be normal, but testosterone and cortisol low and estrogen and prolactin high. It may not display this or other websites correctly. However, we may soon see more data. This reduction in DHT greatly reduces prostate growth and either slows down, stops or reverses hair loss caused by male pattern baldness. Meanwhile, judging by the more than 3,000 PFS patients who have contacted the PFS Foundation since 2012, it appears that men in their late teens, 20s and 30s are most susceptible to the condition. and transmitted securely. Thank you so much for your time. Ive read about him saying this is pro-fat metabolism and Haidut has an article on how hCG is considered a marker for cancer when it is in fact a promotor of cancer in itself because it trigger cell growth. Considering the amount of stress in our daily lives and the constant negative feedbacks from exogenous estrogens leading to GNRH suppression, HCG is probably the best drug there is on the market right now. Both are inconsistent. there is a big thread about the Aussie donut hole - where JK gave us tons of info. Etc Etc really have been feeling like an empty husk like described lately, almost like a part of me was ripped out, but maybe one day i can find it again. Topical TRT will increase DHT even more. Are finasteride-related penile curvature/Peyronie's disease Adverse Event Reports worthy of further clinical investigation? Customers were given free product.. https://www.ncbi.nlm.nih.gov/books/NBK513329/, https://www.niddk.nih.gov/health-information/urologic-diseases/prostate-problems/prostate-enlargement-benign-prostatic-hyperplasia, https://www.pfsfoundation.org/about-pfs-post-finasteride-syndrome/, https://www.pfsfoundation.org/frequently-asked-questions/, https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/020788s028lbl.pdf, https://www.karger.com/Article/Fulltext/497362, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401955/, https://pubmed.ncbi.nlm.nih.gov/17655657/, https://pubmed.ncbi.nlm.nih.gov/27662439/, https://medlineplus.gov/genetics/condition/androgenetic-alopecia/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540144/, https://www.ncbi.nlm.nih.gov/books/NBK482378/, https://www.scitcentral.com/article/19/60/Randomized-Comparative-Research-Study-of-Topical-and-Oral-Finasteride-with-Minoxidil-for-Male-Pattern-Androgenetic-Alopecia-in-Indian-Patients, https://www.ijord.com/index.php/ijord/article/view/394, https://rarediseases.info.nih.gov/diseases/12407/adverse-events-of-5-alpha-reductase-inhibitors, many vitamins are vital for proper hair growth. is a recovery really possible? It is known that post-finasteride syndrome (PFS) patients suffer from treatment-resistant depression and anxiety. synthesis of bile (5-R specifically), which is essential for the digestion of fat and absorption of fat-soluble vitamins. If you have any problems completing this registration, please email support@jackkruse.com and we will assist you. Its also worth noting that in practice, most hair transplantation surgery patients are treated with finasteride before and after the procedure. Bookshelf Like other medications, finasteride went through several large-scale clinical trials before it finally received approval from the FDA. If a pill feels like an overwhelming way to treat male pattern hair loss, this spray with finasteride & minoxidil could be for you. Is that the proper course of action? When you send us your Patient Support form, include a note in your email letting us know youd specifically like to connect with fellow PFS patients who are willing to share their coping strategies. I think its a combination of low energy production due to cellular damage and excess ROS production. In theory, the effects could be additive, but it is not known if the added effects would be beneficial or harmful. In the near future oral allopregnanolone analogs will be available to use in attempting to treat PFS patients. Now, this doesnt mean that finasteride itself cant cause side effects. The treatment consists of taking large doses of B6 and Zinc, along with a few antioxidants. Adverse effects of 5-reductase inhibitors: What do we know, don't know, and need to know. shrink penis. Finasteride blocks the glutathione production leading to mycotoxin build up if you were living or working near mould and not knowing it. As for hair loss shampoos, many include ingredients such as ketoconazole and saw palmetto to block DHT at the scalp level. A: Finasteride, even at low doses, may cause reduced sperm counts, sperm concentration and sperm motility that can result in male infertility in some men. However, it does raise questions about the theory that finasteride has the potential to cause lasting, long-term, severe side effects. My physical and psychological strength is coming back. Minoxidil is a topical medication for treating hair loss. Although finasteride can cause adverse effects, there currently isnt any high quality evidence to show that these continue over the long term. Bookshelf Many men begin to develop sexual performance issues in middle age. If you have a northern European haplotype with a bad SNP profile and you get no or limited sunlight = no sulfated vitamin D3 = altered estradiol = altered testosterone = no progesterone = dehydration due to poor mitochondrial flux = no sex drive = no sex = no oxytocin = Tensegrity 7 blog. Q10: When I sought treatment for PFS from my doctor, all he did was prescribe antidepressants. So combining progesterone + DHEA and allopregnanolone + DHT can be is even better. As a 5-alpha reductase inhibitor, finasteride works by inhibiting the effects of the enzyme thats responsible for converting testosterone into dihydrotestosterone (DHT). Hi Gary, Simultaneously, we monitor FDA trials for potentially promising products in clinical development. Natural solution without any success. But check your bilirubin just in case. Researchers have found low levels of neurosteroids, including allopregnanolone, in the cerebrospinal fluid of post-finasteride syndrome patients. Still, anyone interested in absolute numbers of reported PFS symptoms should review the World Health Organizations VigiBase database of adverse drug reactions (ADRs), which currently contains more than 18,000 finasteride ADRs. Before Bethesda, MD 20894, Web Policies Keep me posted if you like. I am doing a High sensativity blood panel soon, would you be able to also look at my blood work to see what could be the problem with everything i am experiencing?Thanks. According to the Post-Finasteride Syndrome Foundation, a 501(c)(3) nonprofit corporation thats dedicated to raising funds for research into post-finasteride syndrome, men with post-finasteride syndrome have reported the following physical symptoms: Sexual dysfunction, including a decreased sex drive or complete loss of libido, Loss of morning wood and spontaneous erections, Peyronie's disease (growth of scar tissue in the penis), Sexual anhedonia, or loss of pleasure from sexual stimulation and/or arousal, Ejaculation disorders, such as reduced ejaculatory volume and force, Gynecomastia, or male breast growth and sensitivity, Chronic fatigue and lack of energy and enthusiasm, Muscle pain, weakness, cramps, stiffness and twitching, Rhabdomyolysis (rapid breakdown of damaged or injured skeletal muscle), Dry, thinning skin and decreased production of sebum (an oily substance that products your skin), Melasma (a skin condition that involves patches of dark, discolored skin), Lipoatrophy (loss of fat tissue in specific areas of the body), Increased body mass index (BMI) and fat deposition, Reduced HDL cholesterol levels, raised triglycerides and fasting glucose, Increased rheumatoid factor (proteins produced by the immune system), Optic neuropathy (damage to the optic nerve inside the eyes), Ocular toxicity (drug-induced damage to the eyes). Four clicks per day at .25 mL each. Results: At the examination, the three postfinasteride patients reported muscular stiffness, cramps, tremors, and chronic fatigue in the absence of clinical evidence of any muscular disorder or strength reduction. Practo Plus. Researchers have theorized that the reported symptoms of post-finasteride syndrome may not be caused by finasteride itself, but just incidentally associated with finasteride use. Theres also a link between aging and a decline in testosterone levels. Also I jumped the gun on TRT out of frustration and desperation. An Bras Dermatol. Within the medical community, theres debate about whether post-finasteride syndrome is a real medical condition or something thats largely psychological. A few additional tests you can do include: Hey mate I have just stopped finasteride after 7 yrs on it. In some cases, there was no difference in side effect rates between the two treatments. Several different methods are used in hair transplant surgery, including follicular unit extraction (FUE) and follicular unit transplantation (FUT). Careers. FOIA Accessibility I tried only. While this may sound unusual, research backs it up, and even shows that its a specific problem for men who use finasteride. I haven't tried Fens, but relate to the brainfog and depression and no morning wood or it getting spontaneously glorious. Free shipping on Rx medication, if prescribed. You may need to have multiple procedures if your hair loss worsens. I would appreciate some specific help if you could get back to me. What do you think of TRT is PCT to recover from PFS? If youve already done blood tests and want to learn how to interpret them, check out these articles: If DHT is high, then you dont have to focus on boosting DHT, but maybe rather allopregnanolone through increasing 5-AR type 1. National Library of Medicine PEA has been studied in 40 clinical trials involving 6000 subjects over the years and has shown a quite favorable risk/benefit ratio. Q16: I know there are currently no effective treatments for PFS, but can you recommend any special diet, exercise regimen, etc., that might help? wow very helpful articular and explains my symptoms exactly. I am on the transcrotal cream. You are good person for sharing this. prostatis Among the men who used the placebo, 5.1 percent also reported experiencing erectile dysfunction. With proper testing you know where to focus on. Here is how you focus specifically on increasing allopregnanolone: The optimal range for estrogen is around 20pg/ml and if yours is much higher, it would be best to make it a priority to lower it. Its really not the serotonin thats so beneficial. If estrogen is high, focus on lowering that, as estrogen is a potent inducer of serotonin and prolactin. This site uses Akismet to reduce spam. An observational retrospective evaluation of 79 young men with long-term adverse effects after use of finasteride against androgenetic alopecia. I just want to make sure i dont make any mistakes. HCG will increase progesterone or will decrease it? sharing sensitive information, make sure youre on a federal I find this amazing article. Best, Dr. Emer. Hi man, what have you done so far that helped you to 80% recovery? If I work out too much or my job is extra stressful I become symptomatic. Bile also acts as an anti-bacterial and anti-microbial substance which keeps the gut clean and prevents SIBO and SIFO. Finasteride is known to deplete Allopregnanolone and this supplement should help you increase it which may provide relief to brain fog, depression, or insomnia. You also may want to look into using topical finasteride to treat your hair loss. This improvement was blocked by finasteride, which blocks the synthesis of allopregnanolone. Experts believe that the symptoms commonly described as post-finasteride syndrome could be caused by several different factors. I have had retraction of penis and man boobs. 2016 Mar;4(2):245-50. doi: 10.1111/andr.12147. Methods. Borgo F, Macandog AD, Diviccaro S, Falvo E, Giatti S, Cavaletti G, Melcangi RC. 5-reduced steroids are significantly increased in a hyperthyroid state. 5 Apr 16, 2019 #1 Im very desperate for any success recovery story from finasterid side effects.. These customers results have not been independently verified. The only problem is that I have an high PROGESTERONE and High colesterol out of higher range both. You must log in or register to reply here. If youve searched online for information about these side effects, you may have come across mentions of long-lasting, persistent issues that are referred to as post-finasteride syndrome, or PFS. Please enable it to take advantage of the complete set of features! Finasteride was the first on the market and is currently the most widely used inhibitor. Persistent sexual side effects of finasteride: could they be permanent? So optimizing cellular function with CoQ10, necessary vits and minerals, thyroid hormones, neurosteroids, etc., should all be helpful at restoring the problem. After all, if the long-term side effects of finasteride are potentially much worse than going bald, why use it in the first place? Prolactin is a bugger when it comes to mood and cognitive function. My biggest issue is low/no libido. That, according to 2013 study published in the American Society for Reproductive Medicines Fertility and Sterility journal, titled Finasteride use in the male infertility population: effects on semen and hormone parameters. Practo Health Feed. A second factor that may explain the symptoms of post-finasteride syndrome is existing mental illness. Should I stop taking the drug cold turkey, or gradually taper off it? Below, weve looked into reports of post-finasteride syndrome, as well as the latest research on this rare reported side effect of finasteride use. It has a population of 666. Unauthorized use of these marks is strictly prohibited. WebWhen we established the PFS Foundation in 2012, our mission was simple: to facilitate research on the characterization, the underlying biologic mechanisms, and potential treatments of post-finasteride syndrome. We rely on peer-reviewed studies, academic research institutions, and medical associations. DHEA potently increases androsterone levels, and that is how its thought to lower anxiety. For doctors. 2015 Sep;16(3):177-98. doi: 10.1007/s11154-015-9319-y. As I read websites like yours and CDsNuts. Other PFS patients anecdotally report PFS symptoms while using finasteride that get worse after quitting the drug. Therefore, we recommend caution and discussion with your physician about the potential risks before deciding to treat it with SSRIs. I have blood and hormones test results if u want. This action is similar to the action of 5-alpha reductase inhibitors, such as dutasteride and finasteride. Brian fog A: Yes. See? Yes, in general its safer with less sides, but some people have reported similar side effects as fin. Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats. All my symptoms have subsided and improved with this Thanks in advance. Here are a few good ways to increase dopamine: For more a comprehensive guide on boosting dopamine, check out this article: If dopamine is low, then prolactin will most likely be high. Q12: I currently take finasteride but dont have any PFS symptoms. Then he/she implied that its probably all in my head. You can send me an email at menelite101@gmail.com with your labs (and any addition info you might deem relevant) so I can take a look. Curr Urol Rep. 2018 Jun 16;19(8):65. doi: 10.1007/s11934-018-0814-z. I have to recommend Hims to any guy whos experiencing thinning., Cost effective and affordable. Doses have ranged between 1200mg and 3600mg per day without significant side effects. For example, during the second, third and fourth years of the trial, 5.1 percent of men who used finasteride 5mg reported experiencing erectile dysfunction. HCG will most likely increase progesterone, but hopefully, it can stimulate 5AR which will increase allopregnanolone. The https:// ensures that you are connecting to the As a result of this, most medical bodies do not officially recognize post-finasteride syndrome as a medical condition. We are in contact with many women around the world whove told us that, as a direct result of taking finasteride, they suffer from many of the same symptoms as male PFS patients. However, the PFS Foundation strongly discourages the use of finasteride for hair loss by anyone. 2020 Sep;204(3):602. doi: 10.1097/JU.0000000000001168.01. According to a 2017 study published in PeerJ and titled Persistent erectile dysfunction in men exposed to the 5-reductase inhibitors finasteride or dutasteride, 1.2% of young men (defined as those 16 to 42 years old) who took finasteride for 206 days or longer, and had no prior history of sexual dysfunction, developed persistent erectile dysfunction (PED) that lasted an average of 4.2 years after quitting the drug. Photo courtesy of helloclue.com There are[], Photo courtesy of the NIH I have cared for, and[]. >1000ng/dl Testosterone: My Step-by-Step Guide on How I Do It Naturally! Vitamin C for erectile dysfunction: the best vitamin for ED? My goal is to get off Trazodone as quickly as possible, any recomendationsto further aid with insomnia ? Ive moved out of a city recently to an area with a low population. Indeed, delineating the pathophysiological mechanisms underlying PFS will be of paramount importance to the understanding of this syndrome and to development of potential novel therapeutic modalities. This would suggest that tapering might be a safer approach. Diviccaro S, Giatti S, Cioffi L, Falvo E, Herian M, Caruso D, Melcangi RC. Regulatory Effects of Thai Rice By-Product Extracts from. Post-finasteride syndrome: a surmountable challenge for clinicians. (Her story begins around 16:10.). Individual results will vary. Web30 yrs old Male asked about Post finasteride syndrome, 5 doctors answered this and 206 people found it useful. WebMain outcome measures: Neuroactive steroid levels in plasma and cerebrospinal fluid of postfinasteride patients and healthy controls. Alongside thyroid. progesterone -dihydroprogesterone (a very important neuroactive steroid and precursor to allopregnanolone), deoxycorticosterone dihydrodeoxycorticosterone (DHDOC), cortisol 5-dihydrocortisol (for the deactivation of cortisol), aldosterone 5-dihydroaldosterone, which increases the excretion of salt, the opposite of aldosterone, dry skin or thinning of the skin, weight gain, elevated glucose and lipids and worsening of insulin sensitivity(, diminished libido, erectile dysfunction, ejaculatory complaints, penile discomfort, loss of scrotal sensitivity, scrotal discomfort, loss of pubic hair, increased sperm density and, Alcohol (not a long term or good strategy really).